Pentobarbital sodium where to buy
pentobarbital sodium where to buy Barbiturates are known to be surface active [122–124] and hence should be capable of generating liquid membranes at the interface in accordance with Kesting’s liquid membrane hypothesis . There are several instances where the role of surface activity in the biological actions of barbiturates has been indicated [125–127]. In these studies the formation of liquid membranes in series with a supporting membrane, either by barbiturates alone or by barbiturates in association with membrane lipids (lecithin and cholesterol), has been demonstrated. For this, data on the hydraulic permeability in the presence of lecithin-cholesterol-barbiturate mixtures have been utilized. Data on modification in the transport of the relevant permeants, namely γ-aminobutyric acid (GABA), glycine, aspartic acid, serotonin and noradrenaline, in the presence of the liquid membranes generated by a lecithin-cholesterol-barbiturate mixture have been obtained and discussed in the light of the reported biological actions of barbiturates.
Sodium Phenobarbital and sodium pentobarbital were chosen for the study. The critical micelle concentrations (CMC) of aqueous sodium phenobarbital and sodium pentobarbital as determined by the variation of surface tension with concentration at 37°C were found to the 7.5 × 10−5 M and 5.0 × 10−5M respectively.
The hydraulic permeability data at various concentrations in the case of both barbiturates (sodium phenobarbital and sodium pentobarbital) were found to be in accordance with the proportional relationship, Jv= Lp ΔP. The values of Lp at various concentrations of the drugs, estimated from the Jv versus AP plots, are recorded in Table 22. The values of Lp decrease with increasing concentration of the drugs up to their CMC, beyond which they become more or less constant. This trend in the values of Lp is consistent with Kesting’s liquid membrane hypothesis and is indicative of the formation of liquid membranes by the drugs, in series with the supporting membrane. Analysis of the values of Lp in the light of mosaic model [43–45] lends further support to the information of the drug liquid membrane in series with the supporting membrane. The values of Lp thus computed at several concentrations of the drugs below their CMC match with experimentally determined values (Table 22), lending additional support to the formation of the liquid membranes.